Patients at risk of hepatotoxicity should receive intravenous acetylcysteine. Patients who present early should be given activated charcoal. The optimal management of most patients with paracetamol overdose is usually straightforward. Main recommendations (unchanged from previous guidelines): A working group of experts in the area, with representation from all Poisons Information Centres of Australia and New Zealand, were brought together to produce an updated evidence-based guidance. Since the publication of the previous guidelines in 2015, several studies have changed practice. Paracetamol poisoning is the commonest cause of severe acute liver injury. Paracetamol is a common agent taken in deliberate self-poisoning and in accidental overdose in adults and children.
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